Natural Health News — Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease as women with low levels of this nutrient, according to a recent study.
That finding, says lead researcher Cedric F. Garland, DrPH, professor in the Department of Family and Preventive Medicine, prompted him to question the relationship between 25-hydroxyvitamin D – a metabolite produced by the body from the ingestion of vitamin D – and breast cancer survival rates.
Garland and his colleagues performed a statistical analysis of five studies of 25-hydroxyvitamin D obtained at the time of patient diagnosis and their follow-up for an average of nine years. Combined, the studies included 4,443 breast cancer patients.
The results were published in the journal Anticancer Research.
“Vitamin D metabolites increase communication between cells by switching on a protein that blocks aggressive cell division,” said Garland. “As long as vitamin D receptors are present tumour growth is prevented and kept from expanding its blood supply. Vitamin D receptors are not lost until a tumour is very advanced. This is the reason for better survival in patients whose vitamin D blood levels are high.”
Women in the high serum group had an average level of 30 nanograms per millilitre (ng/ml) of 25-hydroxyvitamin D in their blood. The low group averaged 17 ng/ml. The average level in patients with breast cancer in the United States is 17 ng/ml.
“The study has implications for including vitamin D as an adjuvant to conventional breast cancer therapy,” said co-author Heather Hofflich, DO, UC San Diego associate professor in the Department of Medicine.
Try adding vitamin D
Garland suggests we need randomised controlled clinical trials to confirm the findings, but suggested physicians consider adding vitamin D into a breast cancer patient’s standard care now and then closely monitor the patient.
“There is no compelling reason to wait for further studies to incorporate vitamin D supplements into standard care regimens since a safe dose of vitamin D needed to achieve high serum levels above 30 nanograms per milliliter has already been established,” said Garland.
As mentioned above, a 2011 meta-analysis by Garland and colleagues estimated that a serum level of 50 ng/ml is associated with a 50% lower risk of breast cancer.
While there are some variations in absorption, those who consume 4,000 International Units (IU) per day of vitamin D from food or a supplement normally would reach a serum level of 50 ng/ml. Garland urged patients to ask their health care provider to measure their levels before substantially increasing vitamin D intake.
According to the National Institutes of Health, the current recommended daily allowance for vitamin D is 600 IU for adults and 800 IU for people over 70 years old.
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