Your genetic makeup counts for very little when it comes to shaping your immune response. [Image: Bigstock]

Where you live is more influential to immunity than genes

3 October, 2016

Natural Health News — Like fingerprints, our immune systems vary from person to person.

Although we all inherit a unique set of genes that help us respond to infections, recent studies have found that our history and environment – like where and with whom we live – are responsible for 60% to 80% of the differences between individual immune systems, while genetics account for the rest.

In a review published in the journal Trends in Immunology, three immunologists discuss the emerging science of what shapes our immune systems and what it means for our understanding of the immunity.

“Just like it took a while to crack the genetic code, we’re finally starting to crack the immune code, and we’re shifting away from the simplistic idea that there is only one type of immune system,” says lead author Adrian Liston, head of the VIB-KU Leuven Translational Immunology Laboratory in Belgium. “Diversity isn’t just programmed into our genes — it emerges from how our genes respond to the environment.”

What you need to know

» New data suggests that our environments – where we live and who we live with – is more influential in shaping our immune response than our genetic make-up.

» This shaping can explain why, for example, some people are more sensitive to specific viruses than others. What is more, say the researchers, the process of aging only serves to make our individual immune systems more unique.

» The scientists say that we are getting closer to understanding the complex mechanism of the human immune system.

Cellular changes

Long-term infections are responsible for most of the differences between individual immune systems. For example, when a person has herpes or shingles, the virus has more opportunities to interact with the immune system.

These interactions slowly change the cellular makeup of their immune system and make it more sensitive to that specific virus but also easier for other infections to slip past its defenses. People without these infections don’t experience these cellular changes, and even with the occasional cold or fever, their immune systems stay relatively stable over time.

It alters as we age

The exception is when a person is elderly. Researchers haven’t determined exactly why age plays a major role in making our individual immune systems more unique, but they have shown that aging changes how our immune system responds to threats.

As we get older, an organ called the thymus gradually stops producing T-cells, which are made to help to fight off infection. Without new T-cells, older people are more likely to get sick and less likely to respond to vaccines.

Beyond T-cells, aging also seems to broadly change the way our immune systems react.

“A lot of diseases that we associated with aging have an inflammatory component, which suggests there is likely immune involvement,” says Michelle Linterman, a researcher at the Babraham Institute and co-author of the review.

“Understanding how the immune system changes with age is going to be hugely important for treating age-related diseases in the future.”

Environmental impacts

Differences can be overcome, however; studies of people living together have shown that air quality, food, stress levels, sleep patterns, and lifestyle choices had a strong combined effect on our immune responses. For example, couples who cohabitate have more similar immune systems compared to the general public.

The researchers say they would next like to explore how changing our environment could purposefully shape our immune system and potentially affect our health.

“In order to tinker with the immune code, we first need to really understand the influences that shape the immune system,” says Liston. “That’s why it’s actually great that environment is more important than genetics, because we can play with environment.”